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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN7 All Species: 27.27
Human Site: Y350 Identified Species: 75
UniProt: P35236 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35236 NP_002823.2 360 40529 Y350 L H H T L A L Y A G Q L P E E
Chimpanzee Pan troglodytes XP_001140385 339 38349 A330 H H T L A L Y A G Q L P E E P
Rhesus Macaque Macaca mulatta XP_001106613 465 52305 Y455 L H H T L A L Y A G Q L P E E
Dog Lupus familis XP_848933 360 40306 Y350 L H H T L A L Y A A Q L P E G
Cat Felis silvestris
Mouse Mus musculus Q8BUM3 359 40332 Y349 L H H T L A L Y A A Q L P P E
Rat Rattus norvegicus P49445 359 40295 Y349 L H H T L A L Y A A Q L P P E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508421 480 53288 Y470 L H Q T L A L Y A A Q L P E E
Chicken Gallus gallus XP_001232669 363 40663 Y353 L H H T L A L Y A S Q L P E A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_687962 521 58630 Y511 V H H V L S L Y E R Q L R E T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.8 76.3 92.5 N.A. 92.2 91.3 N.A. 61.6 67.4 N.A. 36.2 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 93.8 76.5 94.4 N.A. 95 93.6 N.A. 66.2 78.7 N.A. 46.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 13.3 100 86.6 N.A. 86.6 86.6 N.A. 86.6 86.6 N.A. 53.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 13.3 100 86.6 N.A. 86.6 86.6 N.A. 86.6 86.6 N.A. 66.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 12 78 0 12 78 45 0 0 0 0 12 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 12 0 0 0 12 78 56 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 12 23 0 0 0 0 12 % G
% His: 12 100 78 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 78 0 0 12 89 12 89 0 0 0 12 89 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 12 78 23 12 % P
% Gln: 0 0 12 0 0 0 0 0 0 12 89 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 12 0 0 12 0 0 % R
% Ser: 0 0 0 0 0 12 0 0 0 12 0 0 0 0 0 % S
% Thr: 0 0 12 78 0 0 0 0 0 0 0 0 0 0 12 % T
% Val: 12 0 0 12 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 12 89 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _